RAP80 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520413-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA520413 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
RAP80
Classification
Polyclonal
Conjugate
Unconjugated
Gene
UIMC1
Gene Alias
9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20184, 51720
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q5U5Q9, Q96RL1
Gene Symbols
UIMC1
Immunogen
A 17 amino acid peptide from near the carboxy terminus of human RAP80.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is 293 cell lysate
- PA5-20413 can be used with blocking peptide PEP-0530
- RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR)
- Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation
- Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair
- Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1
- At least four isoforms of RAP80 are known to exist.