PIPA520708
Bora Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520708-Each-of-1 | In Stock | ₹ 46,057.50 |
PIPA520708 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
Bora
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BORA
Gene Alias
6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
306102, 77744, 79866
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q5M864, Q6PGQ7, Q8BS90
Gene Symbols
BORA
Immunogen
A 15 amino acid peptide from near the carboxy terminus of human Bora.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is mouse brain tissue lysate
- PA5-20708 can be used with blocking peptide PEP-0823
- Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis
- Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner
- Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1
- PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1
- Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry
- Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked
- Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation
- At least three isoforms of Bora are known to exist.