RWDD3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520821-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA520821 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
RWDD3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RWDD3
Gene Alias
2510027J23Rik; 3110037C01Rik; AI035684; AI662458; pituitary tumor X2CR1 protein; RSUME; RWD domain containing 3; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; Rwdd3; X2cr1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25950, 65026, 66568
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P0C7N0, Q8VIL2, Q9Y3V2
Gene Symbols
RWDD3
Immunogen
A 17 amino acid peptide from near the amino terminus of human RWDD3.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is mouse kidney tissue lysate
- PA5-20821 can be used with blocking peptide PEP-0935
- RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals
- RWDD3 increases Ikappa-Beta sumoylation and stability
- In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability
- RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways
- Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization
- Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.