GOLPH3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520830-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA520830 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
GOLPH3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Golph3
Gene Alias
4733401N08Rik; 5730410D03Rik; AW413496; coat protein GPP34; coat-protein; Gmx33; golgi peripheral membrane protein 1, 34 kDa; Golgi phosphoprotein 3; golgi phosphoprotein 3 (coat-protein); golgi protein; golgi-associated protein; GOLPH3; GOPP1; GPP34; MIDAS; Mitochondrial DNA absence factor; trans-Golgi protein GMx33; Vps74
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
64083, 66629, 78961
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q9CRA5, Q9ERE4, Q9H4A6
Gene Symbols
Golph3
Immunogen
A 14 amino acid peptide from near the amino terminus of human GOLPH3.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is rat lung tissue lysate
- PA5-20830 can be used with blocking peptide PEP-0944
- GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin
- GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway
- Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro
- Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF
- Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes
- These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.