TMEM38B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520859-Each-of-1 | In Stock | ₹ 49,439.50 |
PIPA520859 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
TMEM38B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TMEM38B
Gene Alias
1600017F22Rik; AA437809; AV051057; bA219P18.1; C9orf87; D4Ertd89e; mg33b; Mitsugumin33B; Mitsugumin-33B; OI14; RGD1305703; RP11-219P18.1; TMEM38B; Transmembrane protein 38B; TRICB; TRIC-B; trimeric intracellular cation channel type B
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
362521, 52076, 55151
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q68FV1, Q9DAV9, Q9NVV0
Gene Symbols
TMEM38B
Immunogen
A 17 amino acid peptide from near the carboxy terminus of human TMEM38B.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is rat thymus tissue lysate
- PA5-20859 can be used with blocking peptide PEP-0973
- TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes
- TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain
- Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores
- Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and μgtrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation
- Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.