SIK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA521139-Each-of-1 | In Stock | ₹ 46,057.50 |
PIPA521139 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
SIK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIK1
Gene Alias
EIEE30; HRT-20; Kid2; MSK; Myocardial SNF1-like kinase; Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase); protein kinase KID2; salt inducible kinase 1; salt-inducible kinase 1; salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK; SIK; Sik1; SIK-1; SNF1-like kinase; SNF1LK
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
150094
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P57059
Gene Symbols
SIK1
Immunogen
An 18 amino acid peptide near the center of human SIK1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is human small intestine tissue lysate
- PA5-21139 can be used with blocking peptide PEP-1253
- SIK1 may mediate the physiological effects of LKB1, including its tumor suppressor function
- SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK
- Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane
- This results in an increase in intracellular sodium in intact mammalian cells
- The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains
- The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K)
- MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway
- Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.