FAM105B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA525638-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA525638 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
FAM105B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
OTULIN
Gene Alias
C79097; deubiquitinating enzyme otulin; FAM105B; family with sequence similarity 105, member B; GUM; gumby; m3Sapc; m7-1Sapc; OTU deubiquitinase with linear linkage specificity; OTU domain-containing deubiquitinase with linear linkage specificity; Otulin; protein FAM105B; ubiquitin thioesterase Gumby; Ubiquitin thioesterase otulin
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
432940, 90268
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q3UCV8, Q96BN8
Gene Symbols
OTULIN
Immunogen
KLH conjugated synthetic peptide between 99-128 amino acids from the central region of human FAM105B
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Otulin is a deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response
- Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex
- Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex
- OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex
- Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis
- In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation
- Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.