Cyclin F Rabbit anti-Human, Polyclonal, Invitrogen™

Description

• PA5-27836 targets Cyclin F in WB applications and shows reactivity with Human samples
• The PA5-27836 immunogen is recombit fragment corresponding to a region within amino acids 444 and 786 of Human Cyclin F
• Store product as a concentrated solution
• Centrifuge briefly prior to opening the vial
• For short-term storage (1-2 weeks), product can be stored at 4°C
• For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles
• This gene encodes a member of the cyclin family
• Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases
• This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box
• The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination
• The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs
• The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.