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PIPA528270

RRAS Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA528270-Each-of-1 In Stock ₹ 46,502.50

PIPA528270 - Each of 1

₹ 46,502.50

In Stock

Quantity

1

Base Price: ₹ 46,502.50

GST (18%): ₹ 8,370.45

Total Price: ₹ 54,872.95

Antigen

RRAS

Classification

Polyclonal

Conjugate

Unconjugated

Gene

RRAS

Gene Alias

AI573426; Harvey rat sarcoma oncogene, subgroup R; Harvey rat sarcoma virus oncogene, subgroup R; oncogene RRAS; p23; ras family small GTP binding protein R-Ras; ras-related protein R-Ras; Ras-related protein R-RAS (P23); related RAS viral (r-ras) oncogene homolog; RRAS

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

20130, 361568, 6237

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Western Blot

Concentration

0.63 mg/mL

Formulation

0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.

D3Z8L7, P10301, P10833

Gene Symbols

RRAS

Immunogen

Recombinant fragment corresponding to a region within amino acids 11 and 218 of Human RRAS

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Recommended positive controls: H1299, HeLaS3, Molt-4, Raji, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2
  • Predicted reactivity: Mouse (93%), Rat (91%), Bovine (96%)
  • Store product as a concentrated solution
  • Centrifuge briefly prior to opening the vial
  • The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families
  • Ras-regulated signal pathways control such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration
  • These GTPases function as molecular switches that control eukaryotic cell function by cycling between two interconvertible forms, a GDP-bound inactive form and a GTP-bound active form
  • The binding of GTP leads to a conformational change in the downstream effector-binding domain of the G-protein
  • The small GTPases are monomeric G-proteins with molecular masses over the range 20-30 kDa
  • Ras is attached to the cell membrane by prenylation
  • Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to 30% of all human tumours
  • The frequency of RAS mutations is among the highest for any gene in human cancer
  • K-ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-ras mutations are common in bladder, kidney, and thyroid carcinomas; N-ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.