PIPA528277
MBD2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA528277-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA528277 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MBD2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Mbd2
Gene Alias
demethylase; DKFZp586O0821; DMTase; MBD2; MBD2a; methyl-CpG binding domain protein 2; methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY-CO-41
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8932
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.48 mg/mL
Formulation
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q9UBB5
Gene Symbols
Mbd2
Immunogen
Recombinant fragment corresponding to a region within amino acids 123 and 349 of Human MBD2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: A431, Jurkat, Raji
- Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (89%), Chicken (82%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing
- It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure
- High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain
- Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3
- In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.