KIR2DS4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529577-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA529577 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
KIR2DS4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KIR2DS4
Gene Alias
CD158 antigen-like family member I; CD158I; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; killer cell immunoglobulin-like receptor 2DS4; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; killer Ig receptor; killer inhibitory receptor 4-1-2; killer-cell immunoglobulin-like receptor; KIR antigen 2DS4; KIR1D; KIR2DS1; KIR2DS4; KIR-2DS4; KIR412; KKA3; MHC class I NK cell receptor; natural killer cell inhibitory receptor; natural killer cell receptor; natural killer-associated transcript 8; NKAT8; NKAT-8; p50 killer cell activating receptor KAR-K1d; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3809
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.89 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P43632
Gene Symbols
KIR2DS4
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 294 of Human KIR2DS4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, Jurkat, Raji
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells
- The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC)
- The gene content of the KIR gene cluster varies among haplotypes, although several "eframework"e genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2)
- The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain
- KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals
- The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.