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PIPA530520

AKAP8L Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA530520-Each-of-1 In Stock ₹ 48,015.50

PIPA530520 - Each of 1

₹ 48,015.50

In Stock

Quantity

1

Base Price: ₹ 48,015.50

GST (18%): ₹ 8,642.79

Total Price: ₹ 56,658.29

Antigen

AKAP8L

Classification

Polyclonal

Conjugate

Unconjugated

Gene

AKAP8L

Gene Alias

A kinase (PRKA) anchor protein 8-like; AKAP8L; AKAP8-like protein; A-kinase anchor protein 8-like; A-kinase anchoring protein 8 like; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; homologous to AKAP95 protein; HRIHFB2018; LOC539700 protein; NAKAP; NAKAP95; neighbor of AKAP; Neighbor of AKAP95; neighbor of A-kinase anchoring protein 95; neighbor of A-kinase-anchoring protein 95; testis tissue sperm-binding protein Li 90mP

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

26993

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

ELISA, Immunoprecipitation, Western Blot

Concentration

1 mg/mL

Formulation

0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.

Q9ULX6

Gene Symbols

AKAP8L

Immunogen

Recombinant fragment corresponding to a region within amino acids 1 and 257 of Human AKAP8L

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Description

  • Recommended positive controls: 293T, A431, Jurkat, Raji
  • Predicted reactivity: Mouse (93%), Rat (93%), Rhesus Monkey (100%)
  • Store product as a concentrated solution
  • Centrifuge briefly prior to opening the vial
  • Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9
  • Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034)
  • Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601)
  • May be involved in nuclear envelope breakdown and chromatin condensation
  • May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899)
  • May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639)
  • Required for cell cycle G2/M transition and histone deacetylation during mitosis
  • In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585)
  • May be involved in regulation of pre-mRNA splicing (PubMed:17594903)
  • [UniProt]