SWAP70 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA530559-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA530559 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SWAP70
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SWAP70
Gene Alias
70kDa; AV235546; FLJ39540; HSPC321; Kiaa0640; KIAA0640 protein; SWA-70 protein; SWAP complex protein; SWAP complex protein, 70 kDa; SWAP switching B-cell complex 70; SWAP switching B-cell complex 70kDa subunit; SWAP70; SWAP-70; SWAP-70 protein; Switch-associated protein 70
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23075
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.7 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q9UH65
Gene Symbols
SWAP70
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 220 of Human SWAP70
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, HeLa, HepG2, Raji
- Predicted reactivity: Mouse (95%), Rat (95%), Chicken (85%), Rhesus Monkey (99%), Bovine (94%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding
- SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation
- As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS
- As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion
- It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.