SIGLEC7 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA530683-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA530683 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SIGLEC7
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIGLEC7
Gene Alias
Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; CD328; CDw328; D-siglec; p75; p75/ AIRM-1; p75/AIRM1; QA79; QA79 membrane protein; sialic acid binding Ig like lectin 7; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; sialic acid-binding Ig-like lectin 7; Siglec; SIGLEC19P; SIGLEC7; SIGLEC-7; SIGLECP2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27036
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q9Y286
Gene Symbols
SIGLEC7
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 199 of Human Siglec 7
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: NCI-H929, IM9
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells
- Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid
- Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide)
- The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
- In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules
- Mediates inhibition of natural killer cells cytotoxicity
- May play a role in hemopoiesis
- Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).