Cyclophilin B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA531172-Each-of-1 | In Stock | ₹ 46,235.50 |
PIPA531172 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,235.50
GST (18%): ₹ 8,322.39
Total Price: ₹ 54,557.89
Antigen
Cyclophilin B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PPIB
Gene Alias
AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5479
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P23284
Gene Symbols
PPIB
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 216 of Human Cyclophilin B
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: A431, HepG2
- Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (86%), Xenopus laevis (87%), Cat (97%), Chicken (92%), Rhesus Monkey (100%), Bovine (95%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506
- Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP)
- Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation
- Thus, providing a possible mechanism of immunosuppression by CsA and FK506
- Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds
- As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.