PIPA532104
DOK6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA532104-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA532104 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DOK6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Dok6
Gene Alias
Docking protein 6; DOK5L; Dok6; Dok-6; Downstream of tyrosine kinase 6; downstream of tyrosine kinases 6; HsT3226; RGD1564376
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
220164, 623279
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.74 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q2MHE5, Q6PKX4
Gene Symbols
Dok6
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 96 and 277 of Human DOK6
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: mouse brain
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (83%), Rhesus Monkey (100%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules
- Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys
- Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue
- Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway
- (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J
- Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth
- J Biol Chem
- 2004 Oct 1;279(40):42072-81
- Epub 2004 Jul 30
- It is also known as DOK6, HsT3226, MGC20785 or IRS
- 0.