ZCCHC6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA554246-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA554246 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
ZCCHC6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ZCCHC6
Gene Alias
6030448M23Rik; AA420405; FLJ13409; HS2; KIAA1711; PAP associated domain containing 6; PAPD6; Terminal uridylyltransferase 7; TUT7; TUTase 7; TUTase7; Zcchc6; Zinc finger CCHC domain-containing protein 6; zinc finger CCHC-type containing 6; zinc finger, CCHC domain containing 6
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
79670
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.05 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q5VYS8
Gene Symbols
ZCCHC6
Immunogen
Recombinant protein corresponding to Human ZCCHC6
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: VARTLNSQPV FEYILHCLRT TYKYFALPHK ITKSSLLKPL NAITCISEHS KEVINHHPDV QTKDDKLKNS VLAQGPGATS SAANTCKVQP LTLKETAESF GSPPKEEMGN EHISVHPENS DCIQ Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 58%
- Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299)
- Essential for both oocyte maturation and fertility
- Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth
- Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299)
- Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828)
- Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7)
- Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation
- Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984)
- In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666)
- Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828)
- Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165)
- Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666)
- TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1
- TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351)
- [UniProt]