SETD1B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA554491-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA554491 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
SETD1B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Setd1b
Gene Alias
AA516740; BC035291; Histone-lysine N-methyltransferase SETD1B; hSET1B; Kiaa1076; KMT2G; LOC100359816; Lysine N-methyltransferase 2G; mKIAA1076; rCG21620-like; SET domain containing 1B; SET domain-containing protein 1B; SET1B; SETD1B
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23067
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.2 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9UPS6
Gene Symbols
Setd1b
Immunogen
Recombinant protein corresponding to Human SETD1B
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: DSLGMEEEVD IETEAVAPEE RPSMLDEPPL PVGVEEPADS REPPEEPGLS QEGAMLLSPE PPAKEVEARP PLSPER Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 54%
- Two distinct signaling pathways activate the host innate immunity against viral infection
- One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response
- VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B
- VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6
- VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region
- Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system
- At least three isoforms of VISA are known to exist.