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PIPA558176

Shootin1 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA558176-Each-of-1 In Stock ₹ 52,065.00

PIPA558176 - Each of 1

₹ 52,065.00

In Stock

Quantity

1

Base Price: ₹ 52,065.00

GST (18%): ₹ 9,371.70

Total Price: ₹ 61,436.70

Antigen

Shootin1

Classification

Polyclonal

Conjugate

Unconjugated

Gene

SHTN1

Gene Alias

4930506M07Rik; Kiaa1598; mKIAA1598; RGD1311558; RIKEN cDNA 4930506M07 gene; shootin 1; Shootin1; shootin-1; shot1; Shtn1; similar to 4930506M07Rik protein

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

57698

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunohistochemistry, Western Blot

Concentration

0.08 mg/mL

Formulation

PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.

A0MZ66

Gene Symbols

SHTN1

Immunogen

Recombinant protein corresponding to Human Shootin1

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Description

  • Immunogen sequence: NRVSMLAVEE YEEMQVNLEL EKDLRKKAES FAQEMFIEQN KLKRQSHLLL QSSIPDQQLL KALDENAKLT QQLEEERIQH QQK Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%
  • SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth
  • Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth
  • Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone
  • Plays also a role in regenerative neurite outgrowth
  • In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex
  • involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.