DUOXA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA559634-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA559634 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
DUOXA1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DUOXA1
Gene Alias
BC019755; dual oxidase activator 1; Dual oxidase maturation factor 1; dual oxidase maturation factor 1 alpha; dual oxidase maturation factor 1 beta; dual oxidase maturation factor 1 delta; dual oxidase maturation factor 1 gamma; Duoxa1; homolog of Drosophila Numb-interacting protein; mol; Nip; Nip1; Numb-interacting protein; NUMBIP; RGD1306601
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
90527
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.2 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q1HG43
Gene Symbols
DUOXA1
Immunogen
Recombinant protein corresponding to Human DUOXA1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: VAHRMQPHRL KAFFNQSVDE DPMLEWSPEE GGLLSPRYRS MADSPKSQDI PLSEASS Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%
- Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis
- They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes
- This gene encodes the DUOX1 activator or maturation factor DUOXA1
- Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes
- This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein
- The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg
- This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation
- Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.