PIPA561019
SKA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA561019-Each-of-1 | In Stock | ₹ 52,332.00 |
PIPA561019 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
SKA1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SKA1
Gene Alias
2810433K01Rik; AV117428; C18orf24; RGD1310784; SKA1; spindle and kinetochore associated complex subunit 1; spindle and kinetochore-associated protein 1; spindle and KT (kinetochore) associated 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
220134
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.05 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q96BD8
Gene Symbols
SKA1
Immunogen
Recombinant protein corresponding to Human SKA1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: ELLNKLELEI QYQEQTNNSL KELCESLEED YKDIEHLKEN IPSHLPQVTV TQSCVKGSDL DPEEPIKVEE PEPVKKPPKE QRSIKEM Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 76%
- Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes
- Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs
- A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset
- Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure
- Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.