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PIPA561380

DDX60 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA561380-Each-of-1 In Stock ₹ 48,905.50

PIPA561380 - Each of 1

₹ 48,905.50

In Stock

Quantity

1

Base Price: ₹ 48,905.50

GST (18%): ₹ 8,802.99

Total Price: ₹ 57,708.49

Antigen

DDX60

Classification

Polyclonal

Conjugate

Unconjugated

Gene

DDX60

Gene Alias

9830118M07; DDX60; DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; DEAD box protein 60; DEAD-box helicase 60; DEXD/H-box helicase 60; mCG11385-like; probable ATP-dependent RNA helicase DDX60; RGD1560014

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

55601

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry

Concentration

0.2 mg/mL

Formulation

PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.

Q8IY21

Gene Symbols

DDX60

Immunogen

Recombinant protein corresponding to Human DDX60

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Description

  • Immunogen sequence: PKADKEAHVM ANKLRKVKKS IEKQKIIDEK SQKKTRNVDQ SLIHEAEHDN LVKCLEKNLE IPQDCTYADQ KAVDTETLQK VFGRV Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 73%
  • DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S
  • cerevisiae Ski2, a cofactor of RNA exosome
  • Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2
  • These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway
  • DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.