COP1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA562890-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA562890 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
COP1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CARD16
Gene Alias
CARD only domain-containing protein 1; CARD only protein; CARD16; CARD-only protein 1; caspase recruitment domain family member 16; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; caspase-1 inhibitor COP; Constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; COP; COP1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; hCOP1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; PSEUDO-ICE; pseudo-IL1B-converting enzyme; putative ubiquitin ligase COP1; RFWD2; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2; RNF200
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114769
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q5EG05
Gene Symbols
CARD16
Immunogen
Recombinant protein corresponding to Human COP1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: LHKGSLYPRI PGLGKELQTG THKLS Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 48%
- Caspase inhibitor
- Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation
- Inhibits the release of IL1B in response to LPS in monocytes
- Also induces NF-kappa-B activation during the pro-inflammatory cytokine response
- Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death
- Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2
- [UniProt]