PIPA563275
SCO2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA563275-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA563275 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
SCO2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Sco2
Gene Alias
CEMCOX1; MYP6; protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; SCO2; SCO2 cytochrome c oxidase assembly protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9997
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
O43819
Gene Symbols
Sco2
Immunogen
Recombinant protein corresponding to Human SCO2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: PTAWHRLSQL KPRVLPGTLG GQALHLRSWL LSRQGPAETG GQGQPQGPGL RTRLLITGLF GAGLGGAWLA LRAEKERLQQ QKRTEALRQA AVGQGDFHLL DHRG Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 26%
- Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane
- Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding
- Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP
- Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.