PIF1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA572989-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA572989 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PIF1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PIF1
Gene Alias
4631410M14; AI449441; ATP-dependent DNA helicase PIF1; ATP-dependent DNA helicase PIF1 {ECO:0000255; C15orf20; DNA helicase-like protein; DNA repair and recombination helicase PIF1; DNA repair and recombination helicase PIF1 {ECO:0000255; HAMAP-Rule:MF_03176}; petite integration frequency 1; PIF; Pif1; PIF1 5'-to-3' DNA helicase; PIF1 5'-to-3' DNA helicase homolog; PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae); PIF1 homolog; Pif1/Rrm3 DNA helicase-like protein; Pif1/Rrm3 DNA-helicase-like protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
208084
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.16 mg/mL
Formulation
PBS with 30% glycerol and 0.05% sodium azide
Gene Accession No.
Q80SX8
Gene Symbols
PIF1
Immunogen
A synthetic peptide made to an internal portion of the human PIF1 protein (between residues 400-500) [UniProt Q9H611]
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PIF1 is a single-stranded (ss) DNA-dependent ATPase as well as a DNA helicase that unwinds DNA in a 5' to 3' direction with respect to the DNA strand on which it binds first
- This protein is critical to DNA replication and telomere length maintenance in Saccharomyces cerevisiae
- The PIF1 gene is highly conserved from yeast to humans
- Mutations in the gene that encodes for PIF1 cause all telomeres to lengthen, suggesting that the PIF1 functions as a catalytic inhibitor of both new telomere formation and telomere elongation
- Human PIF1 preferentially binds telomeric DNA where it inhibits telomerase activity
- PIF1 specifically counteracts the RecQ homolog Sgs1 helicase activity, and degradation of PIF1 is mediated by the ubiquitin-26S proteasome pathway.