DRAK2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA577273-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA577273 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
DRAK2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
STK17B
Gene Alias
3110009A03Rik; AI120141; DAP kinase-related apoptosis-inducing protein kinase 2; death-associated protein kinase-related 2; DRAK 2; DRAK2; serine/threonine kinase 17b; serine/threonine kinase 17b (apoptosis-inducing); serine/threonine-protein kinase 17B; ST17B; STK 17B; Stk17b
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
170904, 9262, 98267
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
O94768, Q8BG48, Q91XS8
Gene Symbols
STK17B
Immunogen
Synthetic peptide corresponding to amino acids 261-310 of Human DRAK2.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
- STK17B (also known as DRAK2) is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis
- STK17B is selectively important for T-cell survival and inhibition of STK17B has therapeutic potential for autoimmune disease
- T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of STK17B can affect autoimmune disease susceptibility without generalized suppression of the immune system
- Protein kinases play important roles in the signal transduction in response to a variety of external stimuli
- Recently, several protein kinases have been identified that may also be involved in apoptotic process
- Overexpression of a serine/threonine kinase, ZIP kinase can cause the morphological changes typical of apoptosis in NIH 3T3 cells
- Sanjo et al, have identified two new protein kinases DRAK1 and DRAK2 (Death Receptor Associated Kinase 1 and 2)
- Both DRAKs and ZIP kinase share significant homology at the amino acid level
- The kinase domains of both DRAKs, ZIP kinase are homologous to DAP (Death-associated protein) kinase, which is involved in the apoptotic signaling induced by interferon-g
- Overexpression of DRAKs in NIH 3T3 cells lead to apoptosis
- These transfection experiments suggest that C-terminal domain of DRAKs are important for induction of apoptosis.