ITGB1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA578028-Each-of-1 | In Stock | ₹ 49,929.00 |
PIPA578028 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,929.00
GST (18%): ₹ 8,987.22
Total Price: ₹ 58,916.22
Antigen
ITGB1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ITGB1
Gene Alias
4633401G24Rik; AA409975; AA960159; Beta OL; beta oligodendroglia; CD29; CSAT antigen; ENSMUSG00000051907; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; Gm9863; gpIIa; integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta 1A precursor; Integrin beta1; integrin beta-1; integrin beta-1 subunit; integrin beta1D; integrin precursor; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; ITGB1; JG22 antigen; MDF2; MSK12; RGD-receptor; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16412, 24511, 3688, 477956
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1.09 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P05556, P09055, P49134
Gene Symbols
ITGB1
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Integrin beta 1/CD29. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Control: A431, HeLa, U87-MG, SK-N-SH, IMR32, SK-N-AS, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat-2, J82 Predicted Reactivity: Xenopus laevis (100%), Cat (100%), Pig (100%), Chicken (100%), Sheep (100%), Bovine (100%) Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes
- ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins
- ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins
- Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug
- ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue
- Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease
- Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta
- More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals
- There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids
- The distribution pattern in adult tissues for integrin beta types are mutually exclusive
- Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.