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PIPA578405

TrkB Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA578405-Each-of-1 In Stock ₹ 49,706.50

PIPA578405 - Each of 1

₹ 49,706.50

In Stock

Quantity

1

Base Price: ₹ 49,706.50

GST (18%): ₹ 8,947.17

Total Price: ₹ 58,653.67

Antigen

TrkB

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Ntrk2

Gene Alias

AI848316; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic receptor tyrosine kinase 2; neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; Ntrk2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; RATTRKB1; Tkrb; Trk B; TRKB; trk-B; trkB protein; trkB tyrosine kinase; TRKB1; Tropomyosin-related kinase B; tyrosine kinase receptor B

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

18212, 25054

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunocytochemistry, Western Blot

Concentration

0.41 mg/mL

Formulation

PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.

P15209, Q63604

Gene Symbols

Ntrk2

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse TrkB. The exact sequence is proprietary.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Positive Control: mouse brain Predicted reactivity: Mouse (100%)
  • Store product as a concentrated solution
  • Centrifuge briefly prior to opening the vial
  • NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system
  • NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF)
  • Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses
  • TrkB is involved in the development and maintenance of the nervous system
  • Moreover, Trk B is a tyrosine kinase gene highly related to Trk A
  • Trk B expression is confined to tissues within the central and peripheral nervous systems
  • The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3
  • TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway
  • Signaling through TrkB leads to cell differentiation
  • Mutations in the TrkB gene have been associated with obesity and mood disorders
  • Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.