RIG-I Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA579148-Each-of-1 | In Stock | ₹ 43,476.50 |
PIPA579148 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,476.50
GST (18%): ₹ 7,825.77
Total Price: ₹ 51,302.27
Antigen
RIG-I
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DDX58
Gene Alias
6430573D20Rik; C330021E21; Ddx58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEAD box protein 58; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; DEAD/H box polypeptide RIG-I; DEAD-box protein 58; DEXD/H-box helicase 58; probable ATP-dependent RNA helicase DDX58; Retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; retinoic acid-inducible gene-I; RIG-1; RIGI; RIG-I; RIG-I-like receptor 1; RLR-1; RNA helicase RIG-I; SGMRT2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
230073, 23586, 297989
Content And Storage
-20°C
Form
Lyophilized
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Concentration
500 μg/mL
Formulation
PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.
O95786, Q6Q899
Gene Symbols
DDX58
Immunogen
E. coli-derived human DDX58 recombinant protein (Position: H871-K925).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL
- Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA
- Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response
- Both MDA5 and RIG-I are RNA helicases and they perform overlapping as well as distinct roles
- RIG-I is activated by dsRNAs without a 5'-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs
- Once activated, both proteins signal through IPS-1 activating transcription factors NF-kappaB and IRF-3 (1) and μgtimately activating apoptosis, cytokine signaling, and inflammation
- RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus (3), paromyxoviruses, Japanese encephalitis virus, and West Nile virus
- MicroRNA-146a has been implicated in feedback inhibition of RIG-I-dependant antiviral response by negatively regulating RIG-I targets TRAF6, IRAK1, and IRAK2
- Recent evidence has implicated RIG-I in the detection of cytosolic DNA through RNA polymerase III activity.