GCAP1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA582201-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA582201 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
GCAP1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Guca1a
Gene Alias
C6orf131; COD3; cone dystrophy 3; CORD14; GC-A; GCAP; GCAP 1; GCAP1; Guanylate cyclase activator 1A; guanylate cyclase activator 1a (retina); guanylate cyclase-activating protein, photoreceptor 1; guanylin 1, retina; guanylyl cyclase-activating protein; guanylyl cyclase-activating protein 1; GUCA; GUCA1; GUCA1A; mGCAP1
Host Species
Rabbit
Purification Method
Anitgen affinity chromatography, Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2978
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.3 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P43080
Gene Symbols
Guca1a
Immunogen
Recombinant protein corresponding to Human GUCA1A
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: EYVAALSLVL KGKVEQKLRW YFKLYDVDGN GCIDRDELLT IIQAIRAINP CSDTTMTAEE FTDTVFSKID VNGDGELSLE EFIEGVQKDQ MLLDTLTRSL DLTRIVRRLQ NGEQDEEGAD EAAEAAG Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors
- The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites
- The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina
- In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified
- Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy
- The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein
- However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.