CDK12 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA582330-Each-of-1 | In Stock | ₹ 49,706.50 |
PIPA582330 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,706.50
GST (18%): ₹ 8,947.17
Total Price: ₹ 58,653.67
Antigen
CDK12
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDK12
Gene Alias
1810022J16Rik; AI646528; CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cdk12; Cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; Crkrs; cyclin dependent kinase 12; cyclin-dependent kinase 12; cyclin-dependent kinase 12 isoform; D11Ertd752e; H KIAA0904; hCDK12; Kiaa0904; Pksc; Protein kinase for splicing component
Host Species
Rabbit
Purification Method
Anitgen affinity chromatography, Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51755
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9NYV4
Gene Symbols
CDK12
Immunogen
Recombinant protein corresponding to Human CDK12
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: GFSAIDTDER NSGPALTESL VQTLVKNRTF SGSLSHLGES SSYQGTGSVQ FPGDQDLRFA RVPLALHPVV GQPFLKAEGS SNSVVHAETK LQNYGELGPG TTGASSSGAG LHWGGPTQSS AY Plays important functions in early cell signaling
- Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters
- Activator of the NF-ELAM1/delta-A site of the E-selectin promoter
- Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers
- Also can bind TRE promoter sequences when heterodimerized with members of the JUN family
- Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
- Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities
- It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.