BAF53B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA582632-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA582632 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
BAF53B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Actl6b
Gene Alias
53 kDa BRG1-associated factor A; 53 kDa BRG1-associated factor B; actin like 6A; actin like 6B; actin-like 6; actin-like 6A; actin-like 6B; actin-like protein 6A; Actin-like protein 6B; actin-like protein 6B {ECO:0000250; actin-related protein 4; actin-related protein Baf53a; Actin-related protein Baf53b; ACTL6; ACTL6A; Actl6b; actl6b {ECO:0000250; Arp4; ArpNa; ArpNalpha; ArpN-alpha; arpNbeta; ARPN-BETA; BAF complex 53 kDa subunit; BAF53; BAF53A; BAF53B; BRG1-associated factor 53A; BRG1-associated factor 53B; hArpN alpha; hArpN beta; INO80 complex subunit K; INO80K; UniProtKB:O94805}
Host Species
Rabbit
Purification Method
Anitgen affinity chromatography, Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51412
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.05 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
O94805
Gene Symbols
Actl6b
Immunogen
Recombinant protein corresponding to Human ACTL6A
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: TVRAGYAGED CPKVDFPTAI GMVVERDDGS TLMEIDGDKG KQGGPTYYID TNALRVPREN MEAISPLKNG MVEDWD Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion
- Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth
- During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state
- The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes
- As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF)
- The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells
- The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth
- ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.