GRF-1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA584293-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA584293 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
GRF-1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ARHGAP35
Gene Alias
6430596G11Rik, AI841135, ARHGAP35, GAP-associated protein p190, glucocorticoid receptor DNA binding factor 1, Glucocorticoid receptor DNA-binding factor 1, Glucocorticoid receptor repression factor 1, GRF1, GRF-1, GRLF1, KIAA1722, LOW QUALITY PROTEIN: rho GTPase-activating protein 35, MGC10745, mKIAA1722, P190 RhoGAP, P190A, p190-A, p190ARHOGAP, p190RhoGAP, rho GAP p190A, Rho GTPase activating protein 35, rho GTPase-activating protein 35, Rho-GAP protein, p190-A, GRLF1
Host Species
Rabbit
Purification Method
Anitgen affinity chromatography, Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2909
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin)
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
Q9NRY4
Gene Symbols
ARHGAP35
Immunogen
Recombinant protein corresponding to Human ARHGAP35
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: VNVDLAFSTL VQLIDKSRGK TKIIPYFEAL KQQSQQIATA KDKYEWLVSR IVKNHNENWL SVSRKMQASP EYQDYVYLEG TQKAKKLF RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division
- Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes
- The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas
- TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells
- The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells
- In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.