PIPA584434
CAPNS2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA584434-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA584434 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
CAPNS2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CAPNS2
Gene Alias
2310005G05Rik; 30K-2; calcium-dependent protease small subunit 2; Calpain small subunit 2; calpain, small subunit 2; CAPNS2; CSS2
Host Species
Rabbit
Purification Method
Anitgen affinity chromatography, Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
84290
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q96L46
Gene Symbols
CAPNS2
Immunogen
Recombinant protein corresponding to Human CAPNS2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: KWQCVYKQYD RDHSGSLGSS QLRGALQAAG FQLNEQLYQM IVRRYANEDG D The Calpain family of proteins are calcium-regulated thiol proteases which have broad endopeptidase activity throughout the body
- Calpain small subunit 2, also known as CSS2 or CAPNS2, is a calcium-dependent protease that is expressed ubiquitously in the cytoplasm
- Part of a heterodimer composed of a small subunit and a large subunit, CSS2 catalyzes proteolysis of various proteins involved in cytoskeletal remodeling and signal transduction
- CSS2 also acts as a chaperone to the larger subunit, mediating its correct folding and conformation
- When bound as a heterodimer, CSS2 is thought to keep the catalytic activity of the large subunit dormant
- After binding calcium, CSS2 is released from the complex, thereby activating the large subunit and allowing CSS2 to translocate from the cytoplasm to the cell membrane
- Defects in the gene encoding CSS2 result in incorrect calpain activity and retarded fetal development, suggesting that CSS2 expression is essential for proper growth.