MLH1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA585129-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA585129 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MLH1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Mlh1
Gene Alias
1110035C23Rik, AI317206, AI325952, AI561766, COCA2, colon cancer, nonpolyposis type 2, DNA mismatch repair protein Mlh1, DNA mismatch repair protein Mlh1-like protein, FCC2, hMLH1, HNPCC, HNPCC2, I79_014127, MGC5172, mismatch repair protein 1, MLH1, MLH-1, mutL homolog 1, mutL homolog 1 (E. coli), mutL homolog 1, colon cancer, nonpolyposis type 2, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), mutL protein homolog 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4292
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Western Blot, Western Blot
Concentration
2 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal, pH 7
Gene Accession No.
P40692
Gene Symbols
Mlh1
Immunogen
Recombinant protein encompassing a sequence within the center region of human MLH1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Keep as concentrated solution
- Predicted reactivity: Mouse (85%), Rat (82%), Pig (91%), Bovine (90%)
- Positive Control: A549, H1299, human MLH1-transfected 293T
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- MLH1 is a DNA mismatch repair protein
- The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time
- An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI)
- These defects in DNA repair pathways have been related to human carcinogenesis
- The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC)
- MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process
- It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.