EFCAB4B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589473-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA589473 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
EFCAB4B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cracr2a
Gene Alias
Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A, calcium release activated channel regulator 2A, calcium release-activated calcium channel regulator 2A, Calcium release-activated channel regulator 2A, CRAC channel regulator 2A, CRAC regulator 2A, Cracr2a, Efcab4b, EF-hand calcium binding domain 4B, EF-hand calcium-binding domain-containing protein 4B, Gm1073, Gm462, RGD1563719
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
381812, 84766
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.01 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q3UP38, Q9BSW2
Gene Symbols
Cracr2a
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_0011384301)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK QLWLQLKKEE PHLLSNFEDF; Positive Samples: Mouse liver; Cellular Location: Cytoplasm CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation
- CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration
- Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1
- Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.