AIPL1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589630-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA589630 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
AIPL1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AIPL1
Gene Alias
A930007I01Rik, AIPL1, AIPL2, aryl hydrocarbon receptor interacting protein like 1, aryl hydrocarbon receptor interacting protein-like 1, aryl hydrocarbon receptor-interacting protein-like 1, aryl-hydrocarbon interacting protein-like 1, aryl-hydrocarbon-interacting protein-like 1, EGK_08083, LCA4
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114230, 23746, 59110
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
Q924K1, Q9JLG9, Q9NZN9
Gene Symbols
AIPL1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human AIPL1 (NP_0551513)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MDAALLLNVE GVKKTILHGG TGELPNFITG SRVIFHFRTM KCDEERTVID DSRQVGQPMH IIIGNMFKLE VWEILLTSMR VHEVAEFWCD TIHTGVYPIL SRSLRQMAQG KDPTEWHVHT CGLANMFAYH TLGYEDLDEL QKEPQPLVFV IELLQVDAPS DYQRETWNLS NHEKMKAVPV LHGEGNRLFK LGRYEEASSK YQEAIICLRN LQTKEKPWEV QWLKLEKMIN TLILNYCQCL LKKEEYYEVL EHTSDILRHH PGIVKAYYVR ARAHAEVWNE AEAKADLQKV LELEPSMQKA VRRELRLLEN RMAEKQEEER LRCRNMLSQG ATQPPAEPPT EPPAQSSTEP PAEPPTAPSA ELSAGPPAEP ATEPPPSPGH SLQH; Positive Samples: U-937, Mouse liver, Mouse heart, Rat liver, Rat brain; Cellular Location: Cytoplasm, Nucleus Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors
- Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor
- Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70
- Aipl1 also associates with the cell cycle regulator NUB1
- It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones
- At least three isoforms of Aipl1 are known to exist.