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PIPA595663

Phospho-CaMKII alpha/beta (Thr306) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA595663-Each-of-1 In Stock ₹ 48,905.50

PIPA595663 - Each of 1

₹ 48,905.50

In Stock

Quantity

1

Base Price: ₹ 48,905.50

GST (18%): ₹ 8,802.99

Total Price: ₹ 57,708.49

Antigen

Phospho-CaMKII alpha/beta (Thr306)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Camk2b

Gene Alias

alpha CaM kinase II, alpha-CaMKII, Ca++/calmodulin-dependent protein kinase II beta subunit, Ca2+/calmodulin-dependent protein kinase II alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta, calcium/calmodulin-dependent protein kinase II alpha, calcium/calmodulin-dependent protein kinase II alpha subunit, calcium/calmodulin-dependent protein kinase II beta, calcium/calmodulin-dependent protein kinase II, beta, calcium/calmodulin-dependent protein kinase type II alpha chain, calcium/calmodulin-dependent protein kinase type II beta chain, calcium/calmodulin-dependent protein kinase type II subunit alpha, Calcium/calmodulin-dependent protein kinase type II subunit beta, caM kinase II subunit alpha, CaM kinase II subunit beta, CaMK II, Camk2a, Camk2b, Camk2d, CaMKII, caMK-II subunit alpha, caMK-II subunit beta, caM-kinase II alpha chain, caM-kinase II beta chain, Ck2b, mKIAA0968, PK2CDD, PKCCD, R74975

Host Species

Rabbit

Purification Method

Antigen Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

12322, 12323, 24245, 25400

Content And Storage

-20°, C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Western Blot

Concentration

∽0.25 mg/mL

Formulation

10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative, pH 7.5

Gene Accession No.

P08413, P11275, P11798, P28652

Gene Symbols

Camk2a, Camk2b

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr306 conjugated to KLH

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Antigen Affinity Purified from Pooled Serum Ca2+/Calmodulin-Dependent Protein Kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular response to a wide variety of intercellular signals (Kennedy, 1998; Schulman and Hanson, 1993)
  • CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+-homeostasis (Gleason et al., 2003; Soderling, 2000; Hudmon and Schulman, 2002)
  • Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II (Meng et al., 2003; Picciotto et al., 1993)
  • Autophosphorylation of Thr305 inhibits the activity CaM Kinase II
  • Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduces LTP and learning (Elgersma et al., 2002).