PIPA595761
RTN1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595761-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595761 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
RTN1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RTN1
Gene Alias
0710005K15Rik, 4930441F12Rik, I79_024631, LOC100750648, MGC133250, MGC40985, Neuroendocrine-specific protein, Nsp, R75279, reticulon 1, reticulon-1, RP23-450G14.1, RTN1, Rtn1-a, Rtn1-b, Rtn1-c, S-rex
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
104001
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.53 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q8K0T0
Gene Symbols
RTN1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_0669591)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: TGVAGVSSAM DHTFSTTSKD GEGSCYTSLI SDICYPPQED STYFTGILQK ENGHVTISES PEELGTPGPS LPDVPGIESR GLFSSDSGIE MTPAESTEVN KILADPLDQM KAEAYKYIDI TRPEEVKHQE QHHPELEDKD LDFKNKDTDI SIKPEGVREP DKPAPVEGKI IKDHLLEEST FAPYIDDLSE EQRRAPQITT PVKITLTEIE PSVETTTQEK TPEKQDICLK PSPDTVPTVT VSEPEDDSPG SITPPSSGTE P; Positive Samples: Mouse lung; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues
- The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22
- The NSP-gene encodes three overlapping proteins, i.e
- reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C)
- These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions
- Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues
- In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A
- Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82
- Reticulon-1B is so far not found in human tissues
- Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).