CCL4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595833-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595833 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CCL4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CCL4
Gene Alias
ACT2, ACT-2, AT744.1, CC chemokine ligand 4, C-C motif chemokine 4, C-C motif chemokine ligand 4, Ccl4, chemokine (C-C motif) ligand 4, G-26, G-26 T-lymphocyte-secreted protein, HC21, immune activation gene 2, immune activation gene-2, immune activation protein 2, LAG1, LAG-1, Lymphocyte activation gene 1 protein, macrophage inflammatory protein 1-beta, macrophage inflammatory protein-1 beta, MGC104418, MGC126025, MGC126026, MIP-1 beta, MIP1b, MIP-1B, Mip1-b, MIP1B1, MIP1beta, MIP-1BETA, MIP-1-beta, MIP1-beta, MIP-1-beta(1-69), MIP-1-beta(3-69), PAT 744, Protein H400, putative MIP-1beta protein, RP23-320E6.8, SCY4A, SCYA2, Scya4, secreted protein G-26, SIS-gamma, small inducible cytokine A4, small inducible cytokine A4 (homologous to mouse Mip-1b), small-inducible cytokine A4, T-cell activation protein 2
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
116637
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.08 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
P50230
Gene Symbols
CCL4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-92 of human CCL4 (NP_0029751)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: SGC-7901 Immunogen sequence: MKLCVTVLSL LMLVAAFCSP ALSAPMGSDP PTACCFSYTA RKLPRNFVVD YYETSSLCSQ PAVVFQTKRS KQVCADPSES WVQEYVYDLE LN CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family
- Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis
- CCL4 is produced by macrophages upon stimulation by bacterial endotoxins
- CCL4 recruits and stimulates various inflammatory cells at sites of inflammation
- CCL4 is produced by lymphocytes, macrophages and dendritic cells
- Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells
- While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes
- Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells
- The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells
- CCL4 binds with high affinity to CCR5 receptors.