Vinculin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595919-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595919 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Vinculin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
VCL
Gene Alias
9430097D22, AA571387, AI462105, AW545629, CMD1W, CMH15, epididymis luminal protein 114, HEL114, metavinculin, meta-vinculin, metavinculin {ECO:0000250, MV, MVCL, RP11-178G16.3, UniProtKB:P18206}, unnamed protein product, Vcl, vcl {ECO:0000250, VIN, vinc, vinc 1, VINC1, Vinculin, vinculin {ECO:0000250
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22330, 305679, 7414
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.76 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
P18206, P85972, Q64727
Gene Symbols
VCL
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 767-1066 of human Vinculin (NP_0033641)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: 293T, NCI-H460, HepG2, BxPC-3, U-87MG, Mouse heart, Mouse brain; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, adherens junction, cytoskeleton, focal adhesion Immunogen sequence: AKREVENSED PKFREAVKAA SDELSKTISP MVMDAKAVAG NISDPGLQKS FLDSGYRILG AVAKVREAFQ PQEPDFPPPP PDLEQLRLTD ELAPPKPPLP EGEVPPPRPP PPEEKDEEFP EQKAGEVINQ PMMMAARQLH DEARKWSSKG NDIIAAAKRM ALLMAEMSRL VRGGSGTKRA LIQCAKDIAK ASDEVTRLAK EVAKQCTDKR IRTNLLQVCE RIPTISTQLK ILSTVKATML GRTNISDEES EQATEMLVHN AQNLMQSVKE TVREAEAASI KIRTDAGFTL RWVRKTPWYQ Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions
- It functions as one of several interacting proteins involved in anchoring F-actin to the membrane
- It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques
- In the assembly of adhesion plaques, the beta subunit of integrin binds to talin
- Talin binds to vinculin that interacts with alpha-actinin and possibly with itself
- Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system
- Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.