HSD3B2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595943-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA595943 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
HSD3B2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HSD3B2
Gene Alias
3 beta HSD II, 3 beta-HSD type II, 3 beta-hydroxysteroid dehydrogenase 2, 3 beta-hydroxysteroid dehydrogenase 6, 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV, 3beta-HSD, 3-beta-HSD adrenal and gonadal type, 3-beta-HSD II, 3-beta-HSD IV, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, delta 5-delta 4-isomerase type II, Delta-5-3-ketosteroid isomerase, HSD3B, Hsd3b1, Hsd3b2, Hsd3b6, HSD-3beta, HSDB, HSDB3B, Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6, hydroxysteroid dehydrogenase-2, delta<5>-3-beta, hydroxysteroid dehydrogenase-6 delta<5>-3-beta, progesterone reductase, SDR11E2, short chain dehydrogenase/reductase family 11E, member 2, Steroid Delta-isomerase
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15493, 3284
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.33 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
P26149, P26439
Gene Symbols
HSD3B2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human HSD3B2 (NP_0001891)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MGWSCLVTGA GGLLGQRIVR LLVEEKELKE IRALDKAFRP ELREEFSKLQ NRTKLTVLEG DILDEPFLKR ACQDVSVVIH TACIIDVFGV THRESIMNVN VKGTQLLLEA CVQASVPVFI YTSSIEVAGP NSYKEIIQNG HEEEPLENTW PTPYPYSKKL AEKAVLAANG WNLKNGDTLY TCALRPTYIY GEGGPFLSAS INEALNNNGI LSSVGKFSTV NPVYVGNVAW AHILALRALR DPKKAPSVRG QFYYISDDTP HQSYDNLNYI LSKEFGLRLD SRWSLPL; Positive Samples: BT-474, U-937, COS1, COS-2, , Mouse brain; Cellular Location: Endoplasmic reticulum membrane, Mitochondrion membrane, Single-pass membrane protein 3 beta-hydroxysteroid dehydrogenase (3beta-HSD), also known as HSD3B1 or HSDB3, is a bifunctional enzyme that plays a crucial role in the synthesis of all classes of hormonal steroids
- Two human 3beta-HSD proteins, designated type I (3beta-HSD) and type II (3beta-HSD2), are expressed by different genes and function in different areas of the body
- Localized to the membrane of the endoplasmic reticulum (ER) and expressed in skin and placenta, 3beta-HSD is the type I protein that catalyzes the oxidative conversion of delta5-ene-3-beta-hydroxy steroid, as well as the conversion of various ketosteroids
- Defects in the gene encoding 3beta-HSD are associated with classic salt wasting, genital ambiguity, hypogonadism, insulin-resistant polycystic ovary syndrome (PCOS) and an increased susceptibility to prostate cancer
- Additionally, congenital deficiency of 3beta-HSD activity results in a severe depletion of steroid formation which can be lethal in young children.