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PIPA596163

DIABLO Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA596163-Each-of-1 In Stock ₹ 46,502.50

PIPA596163 - Each of 1

₹ 46,502.50

In Stock

Quantity

1

Base Price: ₹ 46,502.50

GST (18%): ₹ 8,370.45

Total Price: ₹ 54,872.95

Antigen

DIABLO

Classification

Polyclonal

Conjugate

Unconjugated

Gene

DIABLO

Gene Alias

0610041G12Rik, 1700006L01Rik, AU040403, DFNA64, DIABLO, diablo homolog (Drosophila), diablo homolog, mitochondrial, diablo IAP-binding mitochondrial protein, diablo, IAP-binding mitochondrial protein, diablo-like protein, DIABLO-S, direct IAP binding protein with low PI, direct IAP-binding protein with low pI, FLJ10537, FLJ25049, hCG_1782202, Second mitochondria-derived activator of caspase, Smac, Smac protein, SMAC3

Host Species

Rabbit

Purification Method

Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

288753, 56616, 66593

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration

1.93 mg/mL

Formulation

PBS with 50% glycerol and 0.01% thimerosal, pH 7.3

Gene Accession No.

Q9JIQ3, Q9NR28

Gene Symbols

DIABLO

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_0639401)

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Immunogen sequence: AVPIAQKSEP HSLSSEALMR RAVSLVTDST STFLSQTTYA LIEAITEYTK AVYTLTSLYR QYTSLLGKMN SEEEDEVWQV IIGARAEMTS KHQEYLKLET TWMTAVGLSE MAAEAAYQTG ADQASITARN HIQLVKLQVE EVHQLSRKAE TKLAEAQIEE LRQKTQEEGE ERAESEQEAY LRED Positive Samples: SW620, BT-474, Mouse spleen; Cellular Location: Mitochondrion DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis
  • This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins
  • Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events
  • Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders
  • Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol
  • The release of these proteins, however, occurs via different mechanisms
  • Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).