AIF Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596166-Each-of-1 | In Stock | ₹ 49,528.50 |
PIPA596166 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,528.50
GST (18%): ₹ 8,915.13
Total Price: ₹ 58,443.63
Antigen
AIF
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AIFM1
Gene Alias
AG1, AGR1, Aif, AIFM1, AIFsh2, apoptosis inducing factor mitochondria associated 1, apoptosis inducing factor, mitochondria associated 1, apoptosis-inducing factor 1, mitochondrial, apoptosis-inducing factor, mitochondrion-associated 1, apoptosis-inducing factor, mitochondrion-associated, 1, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, ER protein 18, ER protein 19, ERP18, ERP19, hAG-1, harlequin, Hq, hTLP19, MGC111425, mitochondrial apoptosis-inducing factor 1, NADMR, NAMSD, pcd8, PDCD8, PDIA16, programmed cell death 8 (apoptosis-inducing factor), programmed cell death protein 8, RP3-438D16.2, striatal apoptosis-inducing factor, testicular secretory protein Li 4, TLP19, UNQ713/PRO1376
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
26926, 83533, 9131
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin)
Concentration
0.58 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
O95831, Q9JM53, Q9Z0X1
Gene Symbols
AIFM1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_0041991)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: FPEKGNMGKI LPEYLSNWTM EKVRREGVKV MPNAIVQSVG VSSGKLLIKL KDGRKVETDH IVAAVGLEPN VELAKTGGLE IDSDFGGFRV NAELQARSNI WVAGDAACFY DIKLGRRRVE HHDHAVVSGR LAGENMTGAA KPYWHQSMFW SDLGPDVGYE AIGLVDSSLP TVGVFAKATA QDNPKSATEQ SGTGIRSESE TESEASEITI PPSTPAVPQA PVQGEDYGKG VIFYLRDKVV VGIVLWNIFN RMPIARKIIK DGEQHEDLNE VAKLFNIHED; Positive Samples: SW620, 22Rv1, H460, PC-3, U-937, Mouse liver, Mouse kidney, Mouse heart; Cellular Location: Cytoplasm, Mitochondrion inner membrane, Mitochondrion intermembrane space, Nucleus, perinuclear region Apoptosis Inducing Factor (AIF) causes chromatin condensation and DNA fragmentation
- AIF was recently identified, and cloned
- Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation
- These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins
- Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria
- AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9
- AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli
- AIF is highly conserved between human and mouse and widely expressed
- Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy
- Alternative splicing results in multiple transcript variants of AIF and a related pseudogene has been identified on chromosome 10.