TBK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596169-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA596169 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
TBK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TBK1
Gene Alias
1200008B05Rik, AI462036, AW048562, FLJ11330, FTDALS4, NAK, NF-kappa-B-activating kinase, NF-kB-activating kinase, serine/threonine protein kinase TBK1, serine/threonine-protein kinase TBK1, T2K, TANK binding kinase 1, TANK-binding kinase 1, tbk, TBK1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
29110, 299827, 56480
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
2.98 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
Q9UHD2, Q9WUN2
Gene Symbols
TBK1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TBK1/NAK (NP_0373861)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: DIHTKLLRLS SSQGTIETSL QDIDSRLSPG GSLADAWAHQ EGTHPKDRNV EKLQVLLNCM TEIYYQFKKD KAERRLAYNE EQIHKFDKQK LYYHATKAMT H Positive Samples: Mouse brain; Cellular Location: Cytoplasm TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling
- TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
- NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli
- NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity
- Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB
- The IKK complex contains IKKa, IKK beta, and IKKK
- A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K
- NAK/TBK1 activates IKK beta through direct phosphorylation
- NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors
- NAK/TBK1 functions upstream of NIK and the IKK complex
- NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.