ALKBH8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596592-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA596592 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
ALKBH8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ALKBH8
Gene Alias
4930562C03Rik, 8030431D03Rik, 9430088N01Rik, ABH8, alkB homolog 8, tRNA methyltransferase, AlkB homologue 8, alkB, alkylation repair homolog 8, alkB, alkylation repair homolog 8 (E. coli), Alkbh8, Alkylated DNA repair protein alkB homolog 8, LOW QUALITY PROTEIN: alkylated DNA repair protein alkB homolog 8, probable alpha-ketoglutarate-dependent dioxygenase ABH8, RGD1304687, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, TRM9, TRMT9, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8, tRNA methyltransferase 9 homolog
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
366783, 67667, 91801
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.23 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
Q80Y20, Q96BT7
Gene Symbols
ALKBH8
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ALKBH8 (NP_6201302)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MDSNHQSNYK LSKTEKKFLR KQIKAKHTLL RHEGIETVSY ATQSLVVANG GLGNGVSRNQ LLPVLEKCGL VDALLMPPNK PYSFARYRTT EESKRAYVTL NGKEVVDDLG QKITLYLNFV EKVQWKELRP QALPPGLMVV EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG YEFHYENNNV DKDKPLSGGL PDICESFLEK WLRKGYIKHK PDQMTINQYE; Positive Samples: A-549, NCI-H460, U-87MG, HeLa, K-562; Cellular Location: Cytoplasm, Nucleus Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323)
- Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323)
- Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323)
- Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950)
- Required for normal survival after DNA damage (PubMed:20308323)
- May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).