PRDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA597118-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA597118 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PRDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PRDM2
Gene Alias
4833427P12Rik, E330024L24Rik, G3b, GATA-3 binding protein G3B, GATA-3-binding protein G3B, Gm1033, Gm19732, HUMHOXY1, KMT8, lysine N-methyltransferase 8, MTBzf, MTB-ZF, MTE-binding protein, PR domain 2, PR domain containing 2, with ZNF domain, PR domain zinc finger protein 2, PR domain-containing protein 2, Prdm2, retinoblastoma interacting zinc finger protein, retinoblastoma protein-binding zinc finger protein, retinoblastoma protein-interacting zinc finger protein, RIZ, RIZ1, RIZ2, RP5-1177E19.1, zinc finger protein RIZ, zinc-finger DNA-binding protein, Znfpr1c1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
313678
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.59 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
Q63755
Gene Symbols
PRDM2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRDM2 (NP_0363632)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MNQNTTEPVA ATETLAEVPE HVLRGLPEEV RLFPSAVDKT RIGVWATKPI LKGKKFGPFV GDKKKRSQVK NNVYMWEVYY PNLGWMCIDA TDPEKGNWLR YVNWACSGEE QNLFPLEINR AIYYKTLKPI APGEELLVWY NGEDNPEIAA AIEEERASAR SKRSSPKSRK GKKKSQENKN KGNKIQDIQL KTSEPDFTSA NMRDSAEGPK EDEEKPSASA LEQPATLQEV ASQEVPPELA; Positive Samples: Rat heart; Cellular Location: Nucleus PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif
- Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain
- A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action
- It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.