CD27 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA598297-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA598297 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CD27
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CD27
Gene Alias
CD antigen 27, CD27, CD27 antigen, CD27 molecule, CD27L receptor, LPFS2, S152, S152. LPFS2, sCD27, soluble CD27, T cell activation antigen S152, T14, T-cell activation antigen CD27, TNFRSF7, TNFSF7, Tp55, Tumor necrosis factor receptor superfamily member 7, tumor necrosis factor receptor superfamily, member 7
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
500318, 939
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
4 mg/mL
Formulation
PBS with 50% glycerol and 0.03% ProClin 300, pH 7.4
Gene Accession No.
P26842
Gene Symbols
CD27
Immunogen
Recombinant Human CD27 antigen protein (20-191AA)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30
- The TNF superfamily members are known for the regulation of cell proliferation and death
- In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes
- High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors
- CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals
- CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells
- Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid
- Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies
- RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70
- CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor
- Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.