GNAS Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA598353-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA598353 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
GNAS
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GNAS
Gene Alias
5530400H20Rik, A930027G11Rik, Adenylate cyclase-stimulating G alpha protein, AHO, ALEX, GNAS, NESP55, alpha-stimulatory subunit of GTP-binding protein, alternative gene product encoded by XL-exon, C130027O20Rik, C20orf45, dJ309F20.1.1, dJ806M20.3.3, Extra large alphas protein, G protein alpha subunit, G protein subunit alpha S, GAIPIRRH peptide, G-alpha-8, Galphas, Gnas, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus, gnas {ECO:0000312, GNAS complex locus, GNAS complex locus, SCG6 (secretogranin VI), GNAS1, Gnasxl, Gnpas, GPIPIRRH peptide, GPSA, Gs alpha subunit, GSA, G-SALPHA60A, GSP, GTP-binding regulatory protein (G-s-alpha)., GTP-binding regulatory protein alpha subunit exon 1, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1, guanine nucleotide binding protein alpha s, guanine nucleotide binding protein alpha subunit, guanine nucleotide binding protein, alpha stimulating activity polypeptide 1, guanine nucleotide
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
2778
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
3.04 mg/mL
Formulation
PBS with 50% glycerol and 0.03% ProClin 300, pH 7.4
Gene Accession No.
O95467, P63092, P84996, Q5JWF2
Gene Symbols
GNAS
Immunogen
Recombinant Human Protein ALEX protein (310-404AA)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors
- This gene has a highly complex imprinted expression pattern
- It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons
- Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes
- However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual
- In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others
- An antisense transcript exists, and may regulate imprinting in this region
- Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.