HCAR2/HCAR3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA599937-Each-of-1 | In Stock | ₹ 41,607.50 |
PIPA599937 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,607.50
GST (18%): ₹ 7,489.35
Total Price: ₹ 49,096.85
Antigen
HCAR2/HCAR3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HCAR3
Gene Alias
G protein-coupled receptor 109A; G protein-coupled receptor 109B; G protein-coupled receptor HM74a; GPR109A; GPR109B; G-protein coupled receptor 109A; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74A; G-protein coupled receptor HM74B; GTP-binding protein; HCA2; HCA3; HCAR2; HCAR3; HM74; HM74a; HM74B; hydroxycarboxylic acid receptor 2; hydroxy-carboxylic acid receptor 2; Hydroxycarboxylic acid receptor 3; hydroxy-carboxylic acid receptor 3; niacin receptor 1; Niacin receptor 2; NIACR1; NIACR2; Nicotinic acid receptor; nicotinic acid receptor 2; PUMAG; Puma-g; putative chemokine receptor
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
338442, 8843
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P49019, Q8TDS4
Gene Symbols
HCAR2, HCAR3
Immunogen
A synthesized peptide derived from human HCAR2(Accession Q8TDS4), corresponding to amino acid residues F304-S354.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total GPR109A/B
- Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase
- This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet
- Mediates nicotinic acid-induced apoptosis in mature neutrophils
- Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis
- The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.